{"product_id":"nsj-r30595-100ug","title":"CaMKK Antibody, 100 ug","description":"\u003cp\u003eCalcium\/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The product of this gene belongs to the Serine\/Threonine protein kinase family, and to the Ca(2+)\/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium\/calmodulin-dependent(CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. CaMKK binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity. It catalyzed a 10-fold increase in the total activity of CaMK1 and had no effect on CaMK2. Cotransfection of COS-7 cells with CaMKK and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that CaMKK enhances Camk4-mediated transcriptional regulation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550503665944,"sku":"R30595","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_5a1b5ec9-5f6c-4289-9ed8-9e98c8002112.jpg?v=1768315827","url":"https:\/\/danabiosci.com\/products\/nsj-r30595-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}