{"product_id":"nsj-r30268-100ug","title":"SKP2 Antibody \/ S-phase kinase-associated protein 2, 100 ug","description":"\u003cp\u003eThe F box protein Skp2 (S-phase kinase-associated protein 2) is oncogenic, and its frequent amplification and overexpression correlate with the grade of malignancy of certain tumors. Skp2 controls p300-p53 signaling pathways in cancer cells, making it a potential molecular target for cancer therapy. This gene positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. This study provides evidence of a role for an F-box protein in oncogenesis and establishes SKP2 as a protooncogene causally involved in the pathogenesis of lymphomas.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550519132440,"sku":"R30268","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_9ebd93a1-ffc9-4164-87d4-b7a3c50739d0.jpg?v=1768316129","url":"https:\/\/danabiosci.com\/products\/nsj-r30268-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}