{"product_id":"nsj-r30228-100ug","title":"MAPK1\/3 Antibody \/ ERK1\/2, 100 ug","description":"\u003cp\u003eMAPK1 (ERK2) shares high homology with MAPK3 (ERK1). MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Mitogen-activated protein (MAP) kinases (also known as ERKs) have been established to function as important mediators of signal transduction by growth factor receptors. ERK1\/ERK2-dependent activation of endogenous ribosomal transcription, while inactivation of ERK1\/ERK2 causes an equally immediate reversion to the basal transcription level. ERK1\/ERK2 was found to phosphorylate the architectural transcription factor UBF at amino acids 117 and 201 within HMG boxes 1 and 2, preventing their interaction with DNA. Mutation of these sites inhibited transcription activation and abrogated the transcriptional response to ERK1\/ERK2.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550520574232,"sku":"R30228","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_50a788ef-4f46-49a4-b804-65332fcc4ca5.jpg?v=1768316162","url":"https:\/\/danabiosci.com\/products\/nsj-r30228-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}