{"product_id":"nsj-n1058-25ug","title":"CLEC4E Antibody, 25 ug","description":"\u003cp\u003eCLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRγ, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"25 ug","offer_id":51550561796376,"sku":"N1058-25UG","price":225.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_91159303-ae40-4c7d-8362-7a900f4899fa.jpg?v=1768317306","url":"https:\/\/danabiosci.com\/products\/nsj-n1058-25ug","provider":"Dana Bioscience","version":"1.0","type":"link"}