{"product_id":"nsj-fy13370-100ug","title":"PLEKHB1 Antibody \/ Pleckstrin homology domain-containing family B member 1, 100 ug","description":"\u003cp\u003ePLEKHB1 antibody detects Pleckstrin homology domain-containing family B member 1, a membrane-associated protein encoded by the PLEKHB1 gene on chromosome 11p15.1. PLEKHB1 contains a pleckstrin homology (PH) domain and is involved in maintaining plasma membrane structure, vesicular trafficking, and cell signaling. It is expressed in the retina, brain, and epithelial tissues, where it contributes to cell polarity and intracellular transport. PLEKHB1 is particularly enriched in photoreceptor cells and neuronal synapses, supporting visual signal transmission and neuronal membrane organization.\u003cbr\u003e\u003cbr\u003eStructurally, PLEKHB1 contains a conserved PH domain that binds phosphatidylinositol lipids, anchoring the protein to the inner leaflet of the plasma membrane. It also possesses regions that mediate protein-protein interactions with cytoskeletal and vesicular trafficking partners. PLEKHB1 belongs to the pleckstrin homology domain-containing protein family, which includes PLEKHB2, and participates in membrane dynamics and receptor recycling. Co-localization studies show PLEKHB1 distributed along synaptic membranes and photoreceptor outer segments.\u003cbr\u003e\u003cbr\u003eFunctionally, PLEKHB1 plays an important role in synaptic vesicle trafficking and receptor localization. In the retina, it interacts with proteins such as syntaxin and SNAP25 to regulate photoreceptor membrane stability and neurotransmitter release. In neurons, it supports axonal transport and signal transduction by organizing lipid domains within the plasma membrane. PLEKHB1 may also contribute to cellular polarity through coordination of phosphoinositide signaling at the membrane. During development, PLEKHB1 expression coincides with neural and retinal differentiation.\u003cbr\u003e\u003cbr\u003eDysregulation or mutation of PLEKHB1 has been linked to inherited retinal degenerations and neurological disorders. Its loss disrupts photoreceptor membrane architecture, leading to vision impairment. In cancer biology, PLEKHB1 expression patterns have been used as markers of epithelial polarity and tumor differentiation. Pathway associations include membrane trafficking, phosphatidylinositol signaling, and synaptic vesicle exocytosis. Co-localization with other PH domain proteins suggests a conserved role in regulating membrane-associated signaling complexes.\u003cbr\u003e\u003cbr\u003eThe PLEKHB1 antibody from NSJ Bioreagents is an excellent reagent for studies involving membrane organization, lipid signaling, and vesicular trafficking.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550565794072,"sku":"FY13370","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_1ed0f046-8cc7-4b97-b41c-382a675174fd.jpg?v=1768317386","url":"https:\/\/danabiosci.com\/products\/nsj-fy13370-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}