{"product_id":"nsj-fy13149-100ug","title":"SSH1 Antibody \/ Slingshot protein phosphatase 1, 100 ug","description":"\u003cp\u003eSSH1 antibody detects Slingshot protein phosphatase 1, a serine\/threonine phosphatase that regulates actin filament dynamics by dephosphorylating cofilin. The UniProt recommended name is Slingshot protein phosphatase 1 (SSH1). This cytoplasmic enzyme is crucial for actin cytoskeleton remodeling during cell motility, adhesion, and morphogenesis.\u003cbr\u003e\u003cbr\u003eFunctionally, SSH1 antibody identifies a 1,047-amino-acid phosphatase that activates cofilin by removing inhibitory phosphate groups at serine 3. SSH1 operates downstream of Rho family GTPases and is controlled by 14-3-3 proteins, oxidative signals, and phosphorylation. It promotes lamellipodia formation and cytoskeletal reorganization during migration and neuronal outgrowth.\u003cbr\u003e\u003cbr\u003eThe SSH1 gene is located on chromosome 12q24.13 and is expressed in brain, muscle, and epithelial tissues. SSH1 integrates signals from LIM kinase and Rac\/Cdc42 pathways to coordinate actin turnover and filament severing. Through cofilin activation, SSH1 drives rapid actin recycling necessary for directional movement and cell shape maintenance.\u003cbr\u003e\u003cbr\u003ePathologically, altered SSH1 activity contributes to cancer metastasis, neurological disorders, and cardiac hypertrophy. Dysregulated actin remodeling via SSH1-cofilin imbalance leads to defective migration and cytoskeletal instability. Research using SSH1 antibody supports studies in cytoskeletal dynamics, phosphatase signaling, and cell motility.\u003cbr\u003e\u003cbr\u003eSSH1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect actin-regulating phosphatases. NSJ Bioreagents provides SSH1 antibody reagents optimized for studies in cell migration, cytoskeletal remodeling, and signal transduction.\u003cbr\u003e\u003cbr\u003eStructurally, Slingshot protein phosphatase 1 contains an N-terminal cofilin-binding region and a catalytic domain related to the dual-specificity phosphatase family. This antibody aids in analyzing SSH1's control over actin filament turnover and cellular movement.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552329826584,"sku":"FY13149","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_c3125a14-9e9d-41f8-ac3e-a571941e6801.jpg?v=1768352910","url":"https:\/\/danabiosci.com\/products\/nsj-fy13149-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}