{"product_id":"nsj-fy13111-100ug","title":"RASAL3 Antibody \/ Ras GTPase-activating-like protein 3, 100 ug","description":"\u003cp\u003eRASAL3 antibody detects Ras GTPase-activating-like protein 3, a Ras signaling regulator that acts as a negative modulator of Ras activity in immune cells. The UniProt recommended name is Ras GTPase-activating-like protein 3 (RASAL3). This protein converts active GTP-bound Ras into its inactive GDP-bound form, thereby controlling proliferation and activation signals in lymphocytes and other hematopoietic cells.\u003cbr\u003e\u003cbr\u003eFunctionally, RASAL3 antibody identifies a 944-amino-acid cytoplasmic protein containing C2 and RasGAP domains responsible for lipid membrane binding and GTPase activation. RASAL3 inhibits Ras-dependent pathways, including ERK\/MAPK signaling, limiting excessive immune cell activation and promoting homeostasis. It acts downstream of receptor stimulation to fine-tune immune responses.\u003cbr\u003e\u003cbr\u003eThe RASAL3 gene is located on chromosome 19q13.3 and is highly expressed in natural killer cells, T cells, and macrophages. It serves as a negative feedback regulator of immune activation by controlling Ras signaling intensity following antigen or cytokine stimulation. In NK cells, RASAL3 influences cytotoxic granule release and antiviral responses.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of RASAL3 contributes to immune dysfunction and inflammation. Loss of function enhances Ras activity, promoting lymphoproliferative and autoimmune phenotypes. In cancer, RASAL3 downregulation may facilitate tumor immune evasion by disturbing immune regulation. Research using RASAL3 antibody supports investigations into Ras pathway modulation, immune signaling, and oncogenic Ras control.\u003cbr\u003e\u003cbr\u003eRASAL3 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect RasGAP proteins and Ras activity regulators. NSJ Bioreagents offers RASAL3 antibody reagents optimized for studies in immune signaling, GTPase biology, and cellular regulation.\u003cbr\u003e\u003cbr\u003eStructurally, Ras GTPase-activating-like protein 3 contains an N-terminal C2 lipid-binding domain and a C-terminal catalytic GAP domain. This architecture enables membrane association and inactivation of Ras. This antibody facilitates research on RASAL3's inhibitory role in signal transduction and immune modulation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552331858200,"sku":"FY13111","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b6703324-8877-4e7f-9ab5-0beecee2a96a.jpg?v=1768352973","url":"https:\/\/danabiosci.com\/products\/nsj-fy13111-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}