{"product_id":"nsj-fy12770-100ul","title":"BGLAP Antibody \/ Osteocalcin, 100 ul","description":"\u003cp\u003eBGLAP antibody detects bone gamma carboxyglutamate protein, also known as osteocalcin, encoded by the BGLAP gene. Other identifiers include Bone Gla protein, BGP, and OC. Osteocalcin is a small, secreted non collagenous protein of bone produced exclusively by osteoblasts. It binds calcium and hydroxyapatite in bone matrix, contributing to bone mineralization and remodeling. Because of its specificity to bone forming cells, osteocalcin is widely used as a marker of osteoblast activity and bone turnover.\u003cbr\u003e\u003cbr\u003eBGLAP antibody is widely applied in skeletal biology, endocrinology, and metabolic disease research. Osteocalcin not only functions in bone formation but also acts as a hormone influencing glucose metabolism, insulin sensitivity, and energy expenditure. By detecting BGLAP, researchers can study the dual role of osteocalcin as both a structural bone protein and an endocrine regulator. Circulating osteocalcin levels serve as clinical biomarkers of bone turnover in osteoporosis, fracture healing, and metabolic disorders.\u003cbr\u003e\u003cbr\u003eApplications of BGLAP antibody include western blotting, immunohistochemistry, and ELISA. Western blotting identifies osteocalcin in osteoblast cultures and bone extracts, immunohistochemistry localizes expression in bone tissue sections, and ELISA quantifies circulating osteocalcin in serum or plasma. These complementary approaches provide powerful methods to link bone metabolism with systemic physiology.\u003cbr\u003e\u003cbr\u003eResearch has shown that osteocalcin influences insulin secretion from pancreatic beta cells and testosterone synthesis in Leydig cells, placing bone as an active regulator of endocrine function. Altered osteocalcin expression or signaling is linked to type 2 diabetes, obesity, and reproductive disorders. By applying BGLAP antibody, scientists can evaluate how bone derived signals integrate into whole body metabolic control.\u003cbr\u003e\u003cbr\u003eIn oncology, osteocalcin expression has been observed in certain cancers, including prostate and lung tumors that metastasize to bone. Detection of osteocalcin with antibody based methods provides insights into tumor bone interactions and metastatic microenvironments. This broadens the relevance of BGLAP antibody beyond traditional bone research.\u003cbr\u003e\u003cbr\u003eBGLAP antibody from NSJ Bioreagents provides strong specificity for osteocalcin, ensuring reliable detection in skeletal, metabolic, and cancer biology research.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51552356794648,"sku":"FY12770","price":449.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/nsj-fy12770-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}