{"product_id":"nsj-fy12739-100ug","title":"Annexin A1 Antibody \/ Lipocortin-1 \/ ANXA1, 100 ug","description":"\u003cp\u003eAnnexin A1 antibody detects Annexin A1 (also known as Lipocortin-1 or ANXA1), a calcium-dependent phospholipid-binding protein that mediates anti-inflammatory responses and membrane trafficking. Encoded by the ANXA1 gene on chromosome 9q21.13, this protein belongs to the annexin family characterized by their ability to bind negatively charged phospholipids in a calcium-dependent manner. Annexin A1 contains four annexin repeats and an N-terminal regulatory domain that interacts with phospholipase A2 and formyl peptide receptors. It acts as an effector of glucocorticoid signaling, inhibiting leukocyte transmigration and eicosanoid synthesis to resolve inflammation.\u003cbr\u003e\u003cbr\u003eAnnexin A1 is expressed in many tissues, especially in neutrophils, macrophages, epithelial cells, and the pituitary gland. Upon glucocorticoid stimulation, it translocates to the plasma membrane and is secreted into the extracellular space, where it binds formyl peptide receptor 2 (FPR2\/ALX) on immune cells to inhibit migration and cytokine production. The protein also promotes efferocytosis and tissue repair during inflammation resolution. Dysregulation of Annexin A1 contributes to chronic inflammatory diseases, sepsis, and cancer progression.\u003cbr\u003e\u003cbr\u003eThe Annexin A1 antibody is widely used in immunology, endocrinology, and cancer research to study anti-inflammatory signaling, glucocorticoid response, and cell migration. Western blot analysis typically identifies a 37 kilodalton band corresponding to Annexin A1, while immunohistochemistry reveals cytoplasmic and membrane localization in activated leukocytes and epithelial cells. The antibody is also useful in identifying corticosteroid-mediated gene induction and verifying downstream targets of FPR2 signaling.\u003cbr\u003e\u003cbr\u003eIn cancer biology, Annexin A1 can act as a context-dependent modulator of tumor invasion and metastasis. It regulates cytoskeletal remodeling, apoptosis, and vesicle trafficking, influencing tumor cell motility. The Annexin A1 antibody helps delineate these pathways by enabling accurate detection in tumor and immune microenvironment studies. NSJ Bioreagents provides this antibody validated for its applications to ensure consistent detection across tissue types.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552358596888,"sku":"FY12739","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b542dc33-8c12-44c6-bc84-46bd0fa32847.jpg?v=1768353598","url":"https:\/\/danabiosci.com\/products\/nsj-fy12739-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}