{"product_id":"nsj-fy12703-100ul","title":"Histone H2B (acetyl K16) Antibody \/ HIST2H2BE, 100 ul","description":"\u003cp\u003eHistone H2B (acetyl K16) antibody detects histone H2B specifically when acetylated at lysine 16. Histone H2B is one of the four core histone proteins that package DNA into nucleosomes, the fundamental units of chromatin. Acetylation of lysine residues within histone tails is a key epigenetic modification that influences chromatin structure and gene expression. Acetylation at lysine 16 of H2B is associated with transcriptional activation, chromatin remodeling, and regulation of DNA damage responses.\u003cbr\u003e\u003cbr\u003eHistone H2B (acetyl K16) antibody is widely applied in epigenetics, chromatin biology, and cancer research. By detecting acetylation at this specific site, researchers can examine how histone modifications regulate transcription and genome stability. This modification has been linked to gene activation during cell cycle progression, developmental processes, and stress responses.\u003cbr\u003e\u003cbr\u003e Chromatin immunoprecipitation with Histone H2B (acetyl K16) antibody isolates genomic regions enriched in this modification, providing insight into transcriptional regulation. Western blotting detects acetylated H2B protein, while immunofluorescence highlights nuclear localization and distribution of acetylated histones. These methods allow comprehensive analysis of chromatin modifications in diverse contexts.\u003cbr\u003e\u003cbr\u003eHistone acetylation at lysine 16 plays a role in DNA repair, particularly homologous recombination, by opening chromatin structure at sites of damage. Dysregulation of acetylation is implicated in oncogenesis, neurodegeneration, and developmental disorders. Histone H2B (acetyl K16) antibody supports studies investigating how epigenetic regulation contributes to disease and therapeutic strategies targeting histone modifiers.\u003cbr\u003e\u003cbr\u003eEpigenetic therapies, including histone deacetylase inhibitors, influence acetylation levels at lysine 16 and other residues. By applying this antibody, scientists can evaluate how drugs alter chromatin structure and gene expression. This provides both mechanistic and translational value for cancer and neurological disease research.\u003cbr\u003e\u003cbr\u003eHistone H2B (acetyl K16) antibody from NSJ Bioreagents provides strong specificity for this key histone modification. Its proven reliability ensures accurate detection of epigenetic changes regulating chromatin function.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51552361611544,"sku":"FY12703","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b4ae88d4-28b7-4e03-8fcc-b402942f6b7d.jpg?v=1768353660","url":"https:\/\/danabiosci.com\/products\/nsj-fy12703-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}