{"product_id":"nsj-fy12689-100ul","title":"ELOB Antibody \/ Elongin B, 100 ul","description":"\u003cp\u003eELOB antibody detects elongin B, a protein encoded by the ELOB gene. Elongin B is part of the elongin complex, which also includes elongin C and elongin A. This complex functions as a transcription elongation factor by increasing the rate of RNA polymerase II transcription through transiently pausing sites. Elongin B also acts as a subunit of ubiquitin ligase complexes, linking it to protein degradation pathways.\u003cbr\u003e\u003cbr\u003eELOB antibody is widely applied in transcription research, ubiquitin signaling, and cancer biology. As part of the elongin complex, elongin B facilitates efficient transcription of protein coding genes. In addition, elongin B interacts with Cullin 2 and von Hippel Lindau tumor suppressor protein to form an E3 ubiquitin ligase complex, which targets hypoxia inducible factor alpha for degradation. By detecting ELOB, researchers can study both transcriptional regulation and proteostasis.\u003cbr\u003e\u003cbr\u003e Western blotting with ELOB antibody detects protein expression in nuclear extracts. Immunohistochemistry maps ELOB distribution in proliferative tissues, while immunofluorescence shows localization in the nucleus and cytoplasm. These assays make ELOB antibody a versatile tool for understanding transcription and protein turnover.\u003cbr\u003e\u003cbr\u003eELOB plays critical roles in hypoxia signaling. The elongin complex with von Hippel Lindau protein mediates degradation of HIF1 alpha under normoxia, maintaining cellular oxygen sensing. Dysregulation of this pathway contributes to tumorigenesis and adaptation to hypoxia. By applying ELOB antibody, scientists can investigate how ubiquitin ligase complexes control oxygen sensing and cancer biology.\u003cbr\u003e\u003cbr\u003eBeyond hypoxia signaling, elongin B supports general protein degradation pathways, acting as a ubiquitin like protein that enhances complex stability. It also contributes to viral replication, as some viruses hijack elongin containing complexes for their own protein turnover. The antibody thus supports studies in virology as well as cell biology.\u003cbr\u003e\u003cbr\u003eMutations or dysregulation of ELOB are linked to cancer progression and altered stress responses. Because of its role in both transcription and protein degradation, elongin B integrates signaling networks that control cell survival and growth. ELOB antibody from NSJ Bioreagents provides strong specificity for studying this multifunctional protein across basic and translational research contexts.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51552363086104,"sku":"FY12689","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_5b1acaaa-f2c3-4ddc-a5e6-a8c66c091257.jpg?v=1768353688","url":"https:\/\/danabiosci.com\/products\/nsj-fy12689-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}