{"product_id":"nsj-fy12667-100ug","title":"RAI1 Antibody \/ Retinoic acid-induced protein 1, 100 ug","description":"\u003cp\u003eRAI1 antibody detects Retinoic acid-induced protein 1, a transcriptional regulator implicated in neurodevelopment, circadian rhythm control, and chromatin remodeling. RAI1 functions as a dosage-sensitive transcription factor that modulates neuronal gene expression and behavior. The RAI1 antibody is widely used in genetics, neurobiology, and developmental studies to explore transcriptional regulation and syndromic neurological disorders.\u003cbr\u003e\u003cbr\u003eRAI1 is encoded by the RAI1 gene located on human chromosome 17p11.2. The protein is approximately 1906 amino acids in length and localizes predominantly to the nucleus, where it binds DNA and interacts with chromatin-modifying complexes. RAI1 acts as a transcriptional coactivator that influences gene networks involved in neuronal differentiation, circadian rhythm, and energy balance. Its expression is tightly controlled during embryonic development and in brain regions such as the hypothalamus and cortex.\u003cbr\u003e\u003cbr\u003eThe RAI1 antibody detects a 220 kilodalton band by western blot and reveals nuclear staining under immunofluorescence microscopy. Haploinsufficiency or deletion of RAI1 causes Smith-Magenis syndrome, characterized by developmental delay, sleep disturbances, and behavioral abnormalities. Conversely, duplication of the RAI1 region is associated with Potocki-Lupski syndrome, illustrating the gene's sensitivity to dosage imbalance.\u003cbr\u003e\u003cbr\u003eRAI1 influences circadian rhythm through regulation of CLOCK and BMAL1 targets and modulates neuroplasticity and metabolic pathways. It may also interact with histone-modifying enzymes to alter chromatin accessibility. Dysregulation of RAI1 expression or mutation contributes to neuropsychiatric disorders including autism spectrum disorder, schizophrenia, and intellectual disability.\u003cbr\u003e\u003cbr\u003eBecause RAI1 governs transcriptional networks essential for neuronal function and rhythmic homeostasis, it serves as a vital link between chromatin dynamics and brain physiology. NSJ Bioreagents provides a validated RAI1 antibody optimized for its applications, supporting research into neurodevelopment, transcriptional control, and genomic disorders.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552364724504,"sku":"FY12667","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_531a83be-8b00-463c-9f1c-3b26c884db9c.jpg?v=1768353738","url":"https:\/\/danabiosci.com\/products\/nsj-fy12667-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}