{"product_id":"nsj-fy12642-100ul","title":"TMEM67 Antibody \/ Meckelin, 100 ul","description":"\u003cp\u003eTMEM67 antibody detects meckelin, a transmembrane protein encoded by the TMEM67 gene. Meckelin localizes to primary cilia and the plasma membrane, where it contributes to ciliary structure and signaling. Mutations in TMEM67 cause Meckel syndrome type 3 and Joubert syndrome type 6, autosomal recessive ciliopathies characterized by developmental abnormalities, cystic kidneys, and neurological defects. Meckelin is therefore essential for cilia based signaling pathways, including Wnt and Hedgehog.\u003cbr\u003e\u003cbr\u003eTMEM67 antibody is widely applied in developmental biology, nephrology, and neurogenetics. By detecting meckelin, researchers can study how ciliary proteins regulate organ development and signaling. Ciliary dysfunction underlies a spectrum of disorders known as ciliopathies, linking TMEM67 research to human disease mechanisms.\u003cbr\u003e\u003cbr\u003e Western blot assays detect meckelin in tissue lysates, while immunohistochemistry maps expression in kidney, brain, and liver. Immunofluorescence highlights punctate staining at primary cilia, consistent with its functional localization. These applications provide robust tools for examining ciliary protein biology.\u003cbr\u003e\u003cbr\u003eMeckelin plays roles in regulating planar cell polarity, neuronal migration, and renal morphogenesis. Its dysfunction disrupts signaling and tissue organization, causing developmental defects and organ pathology. By applying TMEM67 antibody, scientists can investigate pathways linking ciliary function to embryogenesis, neurodevelopment, and kidney disease.\u003cbr\u003e\u003cbr\u003eTMEM67 antibody from NSJ Bioreagents delivers dependable specificity for studying meckelin function. Its strong performance ensures accurate detection across developmental and disease contexts.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51552370426136,"sku":"FY12642","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_e48e2b94-95b5-4b01-a668-726793bdbd75.jpg?v=1768353783","url":"https:\/\/danabiosci.com\/products\/nsj-fy12642-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}