{"product_id":"nsj-fy12621-100ul","title":"NDUFS2 Antibody \/ NADH dehydrogenase ubiquinone iron-sulfur protein 2, 100 ul","description":"\u003cp\u003eNDUFS2 antibody detects NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, a mitochondrial respiratory chain complex I subunit encoded by the NDUFS2 gene. NDUFS2 is a core catalytic component of complex I, the largest enzyme of the oxidative phosphorylation system. It contains conserved iron-sulfur clusters that mediate electron transfer from NADH to ubiquinone. By supporting this process, NDUFS2 contributes to ATP generation and cellular energy metabolism.\u003cbr\u003e\u003cbr\u003eNDUFS2 antibody is widely applied in mitochondrial biology, bioenergetics, and disease research. Complex I dysfunction is a hallmark of mitochondrial disorders, neurodegeneration, and metabolic disease. Detection of NDUFS2 provides a marker for complex I assembly and activity. By monitoring NDUFS2 expression, researchers can study mechanisms underlying mitochondrial dysfunction in conditions such as Leigh syndrome, Parkinson disease, and ischemia reperfusion injury.\u003cbr\u003e\u003cbr\u003e Western blot assays detect NDUFS2 protein in mitochondrial fractions, while immunohistochemistry highlights expression in metabolically active tissues such as heart, brain, and muscle. Immunofluorescence reveals punctate mitochondrial staining consistent with its inner membrane localization. These applications allow comprehensive analysis of complex I structure and function.\u003cbr\u003e\u003cbr\u003eMutations in NDUFS2 cause severe mitochondrial disease characterized by impaired energy metabolism, developmental delay, and neurodegeneration. By applying NDUFS2 antibody, scientists can investigate the molecular basis of these disorders and evaluate therapeutic strategies aimed at restoring complex I activity.\u003cbr\u003e\u003cbr\u003eBeyond rare genetic disease, NDUFS2 plays roles in hypoxic adaptation, aging, and cancer metabolism. Changes in NDUFS2 expression affect reactive oxygen species production and signaling, linking mitochondrial function to cellular stress responses. The antibody therefore provides a valuable reagent for broad applications in mitochondrial research.\u003cbr\u003e\u003cbr\u003eNDUFS2 antibody from NSJ Bioreagents offers strong specificity for detecting this essential complex I subunit, supporting reliable studies of oxidative phosphorylation and disease pathogenesis.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51552374423832,"sku":"FY12621","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_c707db77-3f46-43a2-a4cd-31f83edd4eaf.jpg?v=1768353816","url":"https:\/\/danabiosci.com\/products\/nsj-fy12621-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}