{"product_id":"nsj-fy12516-100ul","title":"SNX4 Antibody \/ Sorting nexin 4, 100 ul","description":"\u003cp\u003eSNX4 antibody detects sorting nexin 4, a member of the sorting nexin family encoded by the SNX4 gene. Sorting nexins are characterized by the presence of a phox homology domain that binds phosphoinositides, enabling association with endosomal membranes. SNX4 is primarily involved in endosomal trafficking, cargo sorting, and membrane remodeling. By directing proteins to recycling or degradative pathways, SNX4 maintains cellular homeostasis and regulates receptor signaling.\u003cbr\u003e\u003cbr\u003eSNX4 antibody is widely applied in studies of membrane trafficking, endocytosis, and signal transduction. Sorting nexin 4 is part of the retromer independent recycling pathway and contributes to the trafficking of proteins such as the transferrin receptor. Disruption of SNX4 function impairs endosomal sorting and alters nutrient uptake, receptor turnover, and intracellular signaling dynamics. By detecting SNX4, researchers can explore how sorting nexins control endosomal recycling and cell surface composition.\u003cbr\u003e\u003cbr\u003eIn western blot assays, SNX4 antibody detects protein bands of the expected size in cell and tissue extracts. Immunohistochemistry highlights expression in epithelial and neuronal tissues, while immunofluorescence maps SNX4 distribution on endosomal membranes. These methods support detailed analysis of endosomal dynamics.\u003cbr\u003e\u003cbr\u003eSNX4 has been implicated in neurodegenerative disease and cancer. Altered expression affects autophagy, mitochondrial function, and neuronal survival. In oncology, abnormal SNX4 activity influences growth factor receptor trafficking and signaling, potentially affecting tumor progression. By applying SNX4 antibody, scientists can investigate how sorting nexin mediated trafficking pathways contribute to both normal physiology and disease.\u003cbr\u003e\u003cbr\u003eSNX4 antibody from NSJ Bioreagents provides dependable specificity for exploring membrane trafficking and signaling. Its versatility across assays makes it an essential reagent for cell biology and disease related research.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51552383238424,"sku":"FY12516","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7104795a-d18b-4f6e-a318-e5be0e0c8c62.jpg?v=1768353993","url":"https:\/\/danabiosci.com\/products\/nsj-fy12516-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}