{"product_id":"nsj-fy12500-100ug","title":"TSR1 Antibody \/ Pre-rRNA-processing protein TSR1, 100 ug","description":"\u003cp\u003eTSR1 antibody detects Pre-rRNA-processing protein TSR1 homolog, a ribosome biogenesis factor required for the maturation of the small ribosomal subunit (40S). TSR1 is an essential nucleolar protein that participates in the late stages of pre-18S rRNA processing, ensuring proper ribosome assembly and translation efficiency. The TSR1 antibody is used in studies of ribosome formation, RNA metabolism, and cellular growth control.\u003cbr\u003e\u003cbr\u003eTSR1 is encoded by the TSR1 gene located on human chromosome 17q25.3. The protein is approximately 88 kilodaltons and conserved across eukaryotes, underscoring its critical role in ribosome biogenesis. TSR1 associates with pre-ribosomal particles in the nucleolus and cytoplasm and functions during the transition of 90S to 40S ribosomal precursors. It acts as a structural scaffold that stabilizes pre-rRNA intermediates and recruits processing enzymes necessary for final 18S rRNA cleavage.\u003cbr\u003e\u003cbr\u003eThe TSR1 antibody typically detects an 88-90 kilodalton band on western blot and is useful for immunofluorescence studies showing nucleolar and cytoplasmic localization. Knockdown or mutation of TSR1 disrupts ribosome biogenesis, leading to impaired protein synthesis and activation of nucleolar stress pathways such as p53 stabilization. As a core assembly factor, TSR1 interacts with RIO kinases, NOB1, and other late-acting ribosome maturation proteins.\u003cbr\u003e\u003cbr\u003eIn addition to its canonical role in ribosome formation, TSR1 may contribute to cell cycle progression and proliferation through its control of global translation. Aberrant expression of TSR1 has been observed in several cancers, suggesting a link between elevated ribosome production and tumorigenesis. NSJ Bioreagents provides a validated TSR1 antibody, supporting detailed studies of ribosome assembly, nucleolar dynamics, and translation regulation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552384287000,"sku":"FY12500","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_a14d5d68-1b7e-4b97-9fb4-2f6262343d6d.jpg?v=1768354018","url":"https:\/\/danabiosci.com\/products\/nsj-fy12500-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}