{"product_id":"nsj-fy12393-100ug","title":"LYAR Antibody \/ Cell growth-regulating nucleolar protein, 100 ug","description":"\u003cp\u003eThe LYAR antibody targets Cell growth-regulating nucleolar protein, a zinc finger nucleolar protein encoded by the LYAR gene. Originally identified in human leukemia cells, LYAR plays roles in ribosome biogenesis, rRNA processing, and cell proliferation. Cell growth-regulating nucleolar protein associates with pre-ribosomal complexes and contributes to ribosomal subunit maturation and export. The LYAR antibody provides an essential tool for investigating nucleolar function, ribosome assembly, and growth regulation in both normal and transformed cells.\u003cbr\u003e\u003cbr\u003eCell growth-regulating nucleolar protein contains a C2HC-type zinc finger motif and a nuclear localization signal, directing it to the nucleolus where ribosome synthesis occurs. It participates in the early stages of 60S ribosomal subunit formation by binding pre-rRNA and ribonucleoprotein complexes. The LYAR antibody enables detection of this nucleolar marker, supporting studies into the molecular events that control ribosome production and cellular growth rates. Its expression correlates with proliferative activity in rapidly dividing cells.\u003cbr\u003e\u003cbr\u003eLYAR has emerged as a multifunctional protein involved in transcriptional regulation and cell cycle progression. It interacts with nucleolin and other nucleolar proteins to coordinate ribosomal RNA processing. Beyond ribosome synthesis, Cell growth-regulating nucleolar protein influences p53 signaling and apoptosis by modulating nucleolar stress responses. The LYAR antibody supports analysis of these pathways, helping define how nucleolar integrity links to cell cycle checkpoints and stress-induced growth arrest.\u003cbr\u003e\u003cbr\u003eOverexpression of LYAR has been observed in several cancers, including colorectal, prostate, and hepatocellular carcinoma. It promotes cell proliferation and survival by enhancing rRNA synthesis and suppressing apoptosis. The LYAR antibody enables quantitative assessment of its expression in tumor tissues and cell models, aiding investigation into oncogenic mechanisms involving ribosome biogenesis. In contrast, depletion of LYAR impairs ribosomal maturation and reduces cell growth, underscoring its importance for proliferation control.\u003cbr\u003e\u003cbr\u003eThe LYAR antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, showing distinct nucleolar staining consistent with its localization. NSJ Bioreagents provides this antibody as a validated, high-specificity reagent for use in cell biology, cancer research, and molecular genetics. By supporting precise detection of Cell growth-regulating nucleolar protein, the LYAR antibody advances understanding of ribosome biogenesis, nucleolar stress, and their contributions to tumorigenesis.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552391561496,"sku":"FY12393","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_d8c95085-0ac4-45c6-9017-6654054453a3.jpg?v=1768354183","url":"https:\/\/danabiosci.com\/products\/nsj-fy12393-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}