{"product_id":"nsj-fy12239-100ul","title":"PTBP2 Antibody \/ Polypyrimidine tract binding protein 2, 100 ul","description":"\u003cp\u003ePTBP2 antibody detects polypyrimidine tract binding protein 2, an RNA-binding protein that regulates alternative splicing, mRNA transport, and neuronal differentiation. PTBP2, also known as nPTB, belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and contains four RNA recognition motifs that bind CU-rich elements in pre-mRNA. It is expressed predominantly in neurons and testes, where it orchestrates tissue-specific splicing programs.\u003cbr\u003e\u003cbr\u003eResearch using PTBP2 antibody demonstrates its central role in neuronal development. During neurogenesis, PTBP2 replaces PTBP1 in post-mitotic neurons, reprogramming splicing to promote synaptic maturation and axonal growth. Knockdown of PTBP2 disrupts neuronal differentiation, leading to defective synapse formation and impaired connectivity. Conditional knockout models confirm PTBP2's requirement for brain development, learning, and memory.\u003cbr\u003e\u003cbr\u003eIn disease contexts, PTBP2 dysregulation has been linked to neurological and reproductive disorders. Aberrant PTBP2 expression alters splicing of genes essential for synaptic signaling, contributing to autism spectrum disorders, intellectual disability, and epilepsy. In spermatogenesis, PTBP2 regulates transcripts critical for germ cell development, and its loss results in male infertility.\u003cbr\u003e\u003cbr\u003eCancer studies have also implicated PTBP2 in tumor progression. In gliomas and other cancers, PTBP2 expression modulates alternative splicing of oncogenes and tumor suppressors, altering cell proliferation and survival. By influencing splicing choices, PTBP2 may contribute to cancer cell adaptability and therapy resistance.\u003cbr\u003e\u003cbr\u003ePTBP2 is also a promising target for therapeutic intervention. Manipulating PTBP2 activity or expression has been explored in reprogramming strategies, where suppression of PTBP2 promotes direct conversion of glial cells into functional neurons. Such approaches have potential applications in regenerative medicine and treatment of neurodegenerative disorders.\u003cbr\u003e\u003cbr\u003eAntibodies against PTBP2 are validated for western blot, immunohistochemistry, immunofluorescence, and RNA immunoprecipitation. These reagents enable detection of PTBP2 expression patterns and its association with neuronal transcripts. Clone-based antibodies ensure high specificity across developmental and disease models.\u003cbr\u003e\u003cbr\u003eNSJ Bioreagents supplies this PTBP2 antibody for research into RNA regulation, neuronal differentiation, and disease biology.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51552414761240,"sku":"FY12239","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_2805f8fa-1cec-4ce2-84c7-76f69a5fda34.jpg?v=1768354429","url":"https:\/\/danabiosci.com\/products\/nsj-fy12239-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}