{"product_id":"nsj-fy12225-100ul","title":"PREB Antibody \/ Prolactin regulatory element binding protein, 100 ul","description":"\u003cp\u003ePREB antibody detects prolactin regulatory element binding protein, a transcription factor involved in gene regulation and vesicular trafficking. PREB contains WD-repeat domains that facilitate protein-protein interactions, allowing it to function as a transcriptional regulator and vesicle-associated factor. It is expressed in a variety of tissues, with high levels in brain, pituitary, and pancreas, underscoring its multifunctional roles in development and physiology.\u003cbr\u003e\u003cbr\u003eResearch using PREB antibody has revealed two primary functions of the protein. First, PREB binds to promoter elements of the prolactin gene, regulating hormone expression in the anterior pituitary. By influencing prolactin secretion, PREB impacts reproductive biology, lactation, and endocrine homeostasis. Second, PREB is associated with vesicular transport machinery, where it facilitates protein trafficking between the endoplasmic reticulum and Golgi apparatus. This dual role positions PREB as a regulator of both transcription and intracellular trafficking.\u003cbr\u003e\u003cbr\u003eIn developmental biology, PREB has been shown to be essential for embryogenesis and organogenesis. Knockout models reveal that PREB deficiency leads to embryonic lethality, indicating its necessity for proper gene regulation and cellular organization. Heterozygous models display neurological and metabolic abnormalities, linking PREB to central nervous system development and energy balance.\u003cbr\u003e\u003cbr\u003ePREB has also been studied in the context of neurological and metabolic disorders. Altered PREB expression affects neuroendocrine regulation and insulin secretion. Dysregulation of vesicular trafficking involving PREB has implications for protein misfolding diseases and diabetes. In cancer research, PREB expression changes have been linked to tumor progression, although its exact role remains under investigation.\u003cbr\u003e\u003cbr\u003eAntibodies against PREB are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents allow researchers to study nuclear localization, promoter occupancy, and trafficking-related functions. Clone-based antibodies ensure specificity and reproducibility across experimental systems.\u003cbr\u003e\u003cbr\u003eNSJ Bioreagents supplies this PREB antibody for research into transcriptional regulation, neuroendocrine biology, and vesicular trafficking.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51552415416600,"sku":"FY12225","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_d0118c5e-a9cb-45aa-be77-c92e327c766a.jpg?v=1768354450","url":"https:\/\/danabiosci.com\/products\/nsj-fy12225-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}