{"product_id":"nsj-fy12092-100ug","title":"NGEF Antibody \/ Ephexin 1, 100 ug","description":"\u003cp\u003eNGEF antibody detects Ephexin 1, encoded by the NGEF gene. Ephexin 1 is a guanine nucleotide exchange factor that regulates Rho family GTPases, controlling cytoskeletal dynamics, neuronal signaling, and axon guidance. NGEF antibody provides researchers with a specialized reagent for studying neuronal development, synaptic plasticity, and cell signaling.\u003cbr\u003e\u003cbr\u003eEphexin 1 is activated by ephrin receptor signaling, linking extracellular cues to intracellular Rho GTPase activity. Research using NGEF antibody has shown that it catalyzes GDP to GTP exchange on RhoA, Rac1, and Cdc42, thereby modulating actin cytoskeleton remodeling. These activities govern axon guidance during development, influencing neuronal wiring and brain connectivity.\u003cbr\u003e\u003cbr\u003eStudies with NGEF antibody have revealed that Ephexin 1 is enriched in neurons, particularly in growth cones and synaptic regions. Its regulation by ephrin receptors ensures that axons respond appropriately to repulsive or attractive cues. This makes NGEF a critical player in neural circuit formation and brain development.\u003cbr\u003e\u003cbr\u003eDysregulation of Ephexin 1 has been linked to neurological disorders, including developmental delay, intellectual disability, and autism spectrum disorders. Research using NGEF antibody has shown that mutations or altered expression disrupt axon guidance and synaptic function, impairing neuronal communication. These findings highlight its clinical significance.\u003cbr\u003e\u003cbr\u003eBeyond the nervous system, NGEF may play roles in cytoskeletal regulation in non-neuronal cells. Research using NGEF antibody has suggested functions in cell migration, immune cell trafficking, and tumor invasion. These roles broaden its biological relevance beyond neurodevelopment.\u003cbr\u003e\u003cbr\u003eNGEF antibody is widely applied in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights expression in brain tissue, western blotting quantifies protein levels across developmental stages, and immunofluorescence reveals subcellular localization at synapses. These applications make NGEF antibody indispensable for neurobiology research.\u003cbr\u003e\u003cbr\u003eBy supplying validated NGEF antibody reagents, NSJ Bioreagents supports studies into axon guidance, synaptic signaling, and disease. Detection of Ephexin 1 provides researchers with insight into how guanine nucleotide exchange factors regulate neuronal wiring and function.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552424984856,"sku":"FY12092","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_f2e046e8-e2d1-4f8a-be73-63e451da0569.jpg?v=1768354660","url":"https:\/\/danabiosci.com\/products\/nsj-fy12092-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}