{"product_id":"nsj-fy12070-100ug","title":"TTLL9 Antibody \/ Tubulin tyrosine ligase-like protein 9, 100 ug","description":"\u003cp\u003eTTLL9 antibody detects Tubulin tyrosine ligase-like protein 9, encoded by the TTLL9 gene. Tubulin tyrosine ligase-like protein 9 is a member of the tubulin tyrosine ligase-like family of enzymes and is involved in post-translational modification of tubulin through polyglutamylation. TTLL9 antibody provides researchers with a reagent for studying microtubule regulation, ciliary function, and neuronal biology.\u003cbr\u003e\u003cbr\u003eTubulin tyrosine ligase-like protein 9 belongs to a large family of enzymes that regulate tubulin side chain modifications. Research using TTLL9 antibody has shown that it catalyzes polyglutamylation of tubulin tails, a modification that regulates microtubule interactions with molecular motors and associated proteins. This modification is essential for the structural and functional diversity of the microtubule cytoskeleton.\u003cbr\u003e\u003cbr\u003eStudies with TTLL9 antibody have demonstrated that polyglutamylation mediated by TTLL9 is critical for ciliary function and neuronal signaling. In cilia, TTLL9 activity regulates motility and sensory reception, while in neurons, it influences axonal transport and synaptic function. These findings underscore its broad importance in cellular physiology.\u003cbr\u003e\u003cbr\u003eDysfunction of Tubulin tyrosine ligase-like protein 9 has been linked to ciliopathies and neurological disease. Research using TTLL9 antibody has shown that defects in polyglutamylation cause impaired ciliary motility, sensory dysfunction, and neurodegeneration. In addition, altered TTLL9 activity has been observed in certain cancers, suggesting roles in proliferation and cytoskeletal regulation.\u003cbr\u003e\u003cbr\u003eTTLL9 antibody is widely applied in immunofluorescence, western blotting, and immunohistochemistry. Immunofluorescence highlights modified microtubule arrays, western blotting quantifies expression across tissues, and immunohistochemistry demonstrates localization in brain and ciliated tissues. These applications make TTLL9 antibody indispensable in microtubule research.\u003cbr\u003e\u003cbr\u003eBy supplying validated TTLL9 antibody reagents, NSJ Bioreagents supports studies into tubulin modification, neuronal function, and ciliary biology. Detection of Tubulin tyrosine ligase-like protein 9 provides researchers with insight into how post-translational modification regulates microtubule diversity and disease.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552426230040,"sku":"FY12070","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7fb2d924-84b2-4e8c-9423-48260574d532.jpg?v=1768354688","url":"https:\/\/danabiosci.com\/products\/nsj-fy12070-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}