{"product_id":"nsj-fy12069-100ug","title":"SGMS1 Antibody \/ Sphingomyelin synthase 1, 100 ug","description":"\u003cp\u003eSGMS1 antibody detects Sphingomyelin synthase 1, encoded by the SGMS1 gene. Sphingomyelin synthase 1 is a plasma membrane-associated enzyme that catalyzes the conversion of ceramide and phosphatidylcholine into sphingomyelin and diacylglycerol. SGMS1 antibody provides researchers with a tool for studying sphingolipid metabolism, membrane biology, and signaling processes linked to cell survival and apoptosis.\u003cbr\u003e\u003cbr\u003eSphingomyelin synthase 1 belongs to the sphingomyelin synthase family of enzymes and is localized at the plasma membrane and Golgi apparatus. Research using SGMS1 antibody has shown that the enzyme regulates levels of sphingomyelin, a major structural component of membranes, while simultaneously producing diacylglycerol, a second messenger that activates protein kinase C. This dual metabolic and signaling role highlights SGMS1 as a central regulator of lipid homeostasis and cell signaling pathways.\u003cbr\u003e\u003cbr\u003eStudies with SGMS1 antibody have demonstrated that disruption of SGMS1 alters plasma membrane composition, impairing lipid raft formation and receptor signaling. Deficiency in SGMS1 leads to accumulation of ceramide, which promotes apoptosis, while excess activity favors cell survival and proliferation. This balance underscores the importance of SGMS1 in processes ranging from development to disease.\u003cbr\u003e\u003cbr\u003eDysregulation of Sphingomyelin synthase 1 has been associated with cancer, metabolic disease, and immune dysfunction. Research using SGMS1 antibody has shown that high SGMS1 activity supports tumor cell survival, while inhibition sensitizes cells to apoptosis-inducing agents. In immune biology, SGMS1 influences T cell receptor signaling and cytokine release. These findings make SGMS1 both a biomarker and a potential therapeutic target.\u003cbr\u003e\u003cbr\u003eSGMS1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression in cell lines and tissues, immunohistochemistry demonstrates expression in tumors and metabolic tissues, and immunofluorescence highlights subcellular distribution. These approaches make SGMS1 antibody indispensable for lipid biology research.\u003cbr\u003e\u003cbr\u003eBy supplying validated SGMS1 antibody reagents, NSJ Bioreagents supports studies into sphingolipid metabolism, apoptosis, and disease. Detection of Sphingomyelin synthase 1 provides researchers with insight into how lipid enzymes regulate both membrane composition and signaling.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552426262808,"sku":"FY12069","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_9c0c313f-da06-4be1-b803-792bc142dd87.jpg?v=1768354689","url":"https:\/\/danabiosci.com\/products\/nsj-fy12069-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}