{"product_id":"nsj-fy12012-100ug","title":"RILPL1 Antibody \/ Rab interacting lysosomal protein like 1, 100 ug","description":"\u003cp\u003eRILPL1 antibody detects Rab interacting lysosomal protein like 1, encoded by the RILPL1 gene. Rab interacting lysosomal protein like 1 is a cytoplasmic protein associated with endosomal and lysosomal trafficking pathways and contributes to cellular transport processes. RILPL1 antibody provides researchers with a specific reagent for studying vesicle transport, Rab protein signaling, and lysosomal dynamics.\u003cbr\u003e\u003cbr\u003eRab interacting lysosomal protein like 1 belongs to a small family of proteins that interact with Rab GTPases. Research using RILPL1 antibody has shown that it participates in Rab8 and Rab10 mediated trafficking, regulating transport between recycling endosomes and lysosomes. This activity ensures accurate sorting of proteins and maintenance of membrane compartments. By stabilizing Rab interactions, RILPL1 promotes directional transport required for cell polarity and homeostasis.\u003cbr\u003e\u003cbr\u003eStudies with RILPL1 antibody have demonstrated roles in neuronal cells. Rab interacting lysosomal protein like 1 regulates ciliogenesis and dendritic transport, contributing to neuronal morphology and signaling. Defects in RILPL1 expression have been associated with impaired ciliogenesis, which is linked to developmental disorders and neurodegeneration. These findings highlight its importance in specialized trafficking pathways of neurons.\u003cbr\u003e\u003cbr\u003eIn disease contexts, RILPL1 has been implicated in Parkinson disease. Research using RILPL1 antibody has shown that it interacts with LRRK2, a kinase mutated in familial Parkinson disease. Phosphorylation of Rab proteins by LRRK2 alters RILPL1 mediated trafficking, leading to lysosomal stress and defective autophagy. This suggests that RILPL1 is an important mediator of neurodegenerative pathology through its interaction with disease-associated signaling pathways.\u003cbr\u003e\u003cbr\u003eRILPL1 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies protein levels and detects post-translational changes, immunohistochemistry reveals tissue-specific expression, and immunofluorescence demonstrates subcellular localization to vesicular compartments. These methods make RILPL1 antibody valuable in cell biology and neuroscience research.\u003cbr\u003e\u003cbr\u003eBy providing validated RILPL1 antibody reagents, NSJ Bioreagents supports studies into Rab signaling, vesicle trafficking, and neurodegeneration. Detection of Rab interacting lysosomal protein like 1 provides researchers with insights into how vesicular transport pathways influence development and disease.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552430850328,"sku":"FY12012","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_dd420f27-d943-48cd-b801-6958bc2f7125.jpg?v=1768354779","url":"https:\/\/danabiosci.com\/products\/nsj-fy12012-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}