{"product_id":"nsj-fy12001-100ug","title":"ROR2 Antibody \/ Receptor tyrosine kinase-like orphan receptor 2, 100 ug","description":"\u003cp\u003eROR2 antibody detects Receptor tyrosine kinase-like orphan receptor 2, encoded by the ROR2 gene. Receptor tyrosine kinase-like orphan receptor 2 is a transmembrane protein that belongs to the receptor tyrosine kinase family and is an important regulator of development, cell signaling, and skeletal formation. ROR2 antibody provides researchers with a specific reagent for studying Wnt signaling pathways, embryogenesis, and disease processes associated with developmental abnormalities.\u003cbr\u003e\u003cbr\u003eReceptor tyrosine kinase-like orphan receptor 2 contains an extracellular cysteine-rich domain, an immunoglobulin-like domain, and a tyrosine kinase-like cytoplasmic domain. Research using ROR2 antibody has shown that it functions as a receptor for non-canonical Wnt signaling, particularly Wnt5a. Activation of ROR2 modulates cytoskeletal dynamics, cell migration, and planar cell polarity signaling. These activities are essential for tissue morphogenesis during development.\u003cbr\u003e\u003cbr\u003eStudies with ROR2 antibody have revealed that mutations in the ROR2 gene cause developmental disorders such as Robinow syndrome and brachydactyly type B. These conditions are characterized by skeletal malformations, short stature, and craniofacial abnormalities. Research into patient-derived cells has demonstrated that loss of ROR2 disrupts Wnt signaling, impairing cartilage development and bone growth. These findings highlight the essential role of ROR2 in skeletal patterning.\u003cbr\u003e\u003cbr\u003eIn cancer biology, ROR2 has emerged as a regulator of tumor progression. Research using ROR2 antibody has demonstrated that ROR2 promotes migration and invasion in melanoma, renal cell carcinoma, and osteosarcoma. Overexpression correlates with poor prognosis, likely due to its ability to activate signaling pathways that remodel the cytoskeleton and extracellular matrix. Targeting ROR2 is under investigation as a therapeutic strategy in oncology.\u003cbr\u003e\u003cbr\u003eROR2 antibody is widely applied in western blotting, immunohistochemistry, and flow cytometry. Western blotting detects full-length receptor and truncated isoforms, immunohistochemistry localizes expression to developing skeletal tissues and tumors, and flow cytometry quantifies receptor surface expression on cells. These applications make ROR2 antibody indispensable for developmental biology and cancer research.\u003cbr\u003e\u003cbr\u003eBy supplying validated ROR2 antibody reagents, NSJ Bioreagents supports studies into skeletal development, Wnt signaling, and cancer. Detection of Receptor tyrosine kinase-like orphan receptor 2 provides researchers with insights into how receptor tyrosine kinases integrate developmental cues with disease processes.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51552431538456,"sku":"FY12001","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_465128ec-82b1-4366-b169-d847d17acf46.jpg?v=1768354796","url":"https:\/\/danabiosci.com\/products\/nsj-fy12001-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}