{"product_id":"nsj-f55063-0-1ml","title":"Phospho-Histone H2AX Antibody (pS139), 0.1 ml","description":"\u003cp\u003eVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.1 ml","offer_id":51552440025368,"sku":"F55063-0.1ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7aa8cdcf-d3f8-44a1-8535-1def0cff1316.jpg?v=1768354995","url":"https:\/\/danabiosci.com\/products\/nsj-f55063-0-1ml","provider":"Dana Bioscience","version":"1.0","type":"link"}