{"product_id":"nsj-f54492-0-2ml","title":"PCNA Antibody, 0.2 ml","description":"\u003cp\u003eAuxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 ml","offer_id":51552514572568,"sku":"F54492-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_21ae70ea-88ad-4722-b378-22a087ae8d00.jpg?v=1768356730","url":"https:\/\/danabiosci.com\/products\/nsj-f54492-0-2ml","provider":"Dana Bioscience","version":"1.0","type":"link"}