{"product_id":"nsj-f54481-0-05ml","title":"IRF3 Antibody, 0.05 ml","description":"\u003cp\u003eKey transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA\/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.05 ml","offer_id":51552515752216,"sku":"F54481-0.05ML","price":205.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_ebbd5f0a-312b-43c4-8c7f-2e5c83ead40c.jpg?v=1768356769","url":"https:\/\/danabiosci.com\/products\/nsj-f54481-0-05ml","provider":"Dana Bioscience","version":"1.0","type":"link"}