{"product_id":"nsj-f54104-0-2ml","title":"BRCA2, 0.2 ml","description":"\u003cp\u003eInvolved in double-strand break repair and\/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and DSS1, and is required to prevent R-loop- associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:\u003ca href=\"http:\/\/www.uniprot.org\/citations\/24896180\" target=\"_blank\"\u003e24896180\u003c\/a\u003e). [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 ml","offer_id":51552578109720,"sku":"F54104-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_1246df4f-ac69-4297-a7e5-80a6a5c05ea4.jpg?v=1768357873","url":"https:\/\/danabiosci.com\/products\/nsj-f54104-0-2ml","provider":"Dana Bioscience","version":"1.0","type":"link"}