{"product_id":"nsj-f53289-0-4ml","title":"Zebrafish LC3B Antibody \/ MAP1LC3B, 0.4 ml","description":"\u003cp\u003eMicrotubule-associated proteins 1A\/1B light chain 3B (Map1lc3b) is a highly conserved autophagy-related protein in zebrafish (Danio rerio), serving as a key component of the autophagosome membrane. It is the zebrafish ortholog of mammalian LC3B, which is widely used as a molecular marker for autophagosomes and autophagic activity.\u003c\/p\u003e\u003cp\u003eZebrafish Map1lc3b is initially synthesized as a cytosolic precursor (LC3-I), which undergoes post-translational cleavage and lipidation to form LC3-II, the autophagosome-associated form. This lipidated form binds to autophagic membranes, making Map1lc3b essential for autophagosome formation, maturation, and cargo recruitment.\u003c\/p\u003e\u003cp\u003eIn zebrafish, map1lc3b is expressed during early embryogenesis and throughout development, with increased expression observed in tissues undergoing high autophagic flux. It has become a widely used marker in transgenic zebrafish lines (e.g., Tg(CMV:map1lc3b-GFP)) for live imaging of autophagy under physiological and stress conditions, including nutrient deprivation, neurodegeneration, and toxin exposure.\u003c\/p\u003e\u003cp\u003eThe conserved role of Map1lc3b in autophagy makes it an important tool for studying cellular homeostasis, developmental processes, and disease models in zebrafish.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51552619069720,"sku":"F53289-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_17fa3e73-0d34-455a-b13f-b2f72d4e7c77.jpg?v=1768358875","url":"https:\/\/danabiosci.com\/products\/nsj-f53289-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}