{"product_id":"nsj-f52344-0-4ml","title":"SUMO-2 Antibody, 0.4 ml","description":"\u003cp\u003eUbiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51552658456856,"sku":"F52344-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b39f2942-de0f-4906-814d-6762f8b1d1b9.jpg?v=1768359563","url":"https:\/\/danabiosci.com\/products\/nsj-f52344-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}