{"product_id":"nsj-f52112-0-08ml","title":"TSC2 Antibody, 0.08 ml","description":"\u003cp\u003eIn complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":51552663077144,"sku":"F52112-0.08ML","price":205.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_3b669dbc-005d-4f71-bbf4-8022c07bff9e.jpg?v=1768359684","url":"https:\/\/danabiosci.com\/products\/nsj-f52112-0-08ml","provider":"Dana Bioscience","version":"1.0","type":"link"}