{"product_id":"nsj-f50739-0-4ml","title":"SMAD4 Antibody, 0.4 ml","description":"\u003cp\u003eIn muscle physiology, SMAD4 plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2\/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1\/5\/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT\/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51552713277720,"sku":"F50739-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7f4e7285-719d-4ad9-9b8f-625fffbe1940.jpg?v=1768360372","url":"https:\/\/danabiosci.com\/products\/nsj-f50739-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}