{"product_id":"nsj-f50682-0-4ml","title":"TrkA Antibody \/ NTRK1, 0.4 ml","description":"\u003cp\u003eThis gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Its presence leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Isoform 3 is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. [Isoform 3 information courtesy of UniProt].\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51552719733016,"sku":"F50682-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_58b00659-5b96-45bf-a5e3-53be0f7500da.jpg?v=1768360440","url":"https:\/\/danabiosci.com\/products\/nsj-f50682-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}