{"product_id":"nsj-f48688-0-4ml","title":"p-HER2 Antibody (pS1151), 0.4 ml","description":"\u003cp\u003eThis gene encodes a member of the epidermal growth factor  (EGF) receptor family of receptor tyrosine kinases. This protein  has no ligand binding domain of its own and therefore cannot bind  growth factors. However, it does bind tightly to other ligand-bound  EGF receptor family members to form a heterodimer, stabilizing  ligand binding and enhancing kinase-mediated activation of  downstream signalling pathways, such as those involving  mitogen-activated protein kinase and phosphatidylinositol-3 kinase.  Allelic variations at amino acid positions 654 and 655 of isoform a  (positions 624 and 625 of isoform b) have been reported, with the  most common allele, Ile654\/Ile655, shown here. Amplification and\/or  overexpression of this gene has been reported in numerous cancers,  including breast and ovarian tumors. Alternative splicing results  in several additional transcript variants, some encoding different  isoforms and others that have not been fully characterized.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51552817938712,"sku":"F48688-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_135a732f-2695-496d-9e42-edb655a5cee7.jpg?v=1768361809","url":"https:\/\/danabiosci.com\/products\/nsj-f48688-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}