{"product_id":"nsj-f48602-0-08ml","title":"Phospho-NANOG Antibody (pS285), 0.08 ml","description":"\u003cp\u003eNANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cels proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":51552824197400,"sku":"F48602-0.08ML","price":205.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_9f871e4d-e9ee-4b1a-bf86-7541ed75b0b8.jpg?v=1768361910","url":"https:\/\/danabiosci.com\/products\/nsj-f48602-0-08ml","provider":"Dana Bioscience","version":"1.0","type":"link"}