{"product_id":"nsj-f47894-0-4ml","title":"PROX1 Antibody \/ Prospero homeobox 1, 0.4 ml","description":"\u003cp\u003eThe expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51552844120344,"sku":"F47894-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_03add3cb-7535-411d-a741-7c132e4a5173.jpg?v=1768362426","url":"https:\/\/danabiosci.com\/products\/nsj-f47894-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}