{"product_id":"nsj-f47336-0-08ml","title":"Lats2 Antibody, 0.08 ml","description":"\u003cp\u003eNegative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1\/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1\/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1\/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1\/S transition by down-regulating cyclin E\/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":51552867942680,"sku":"F47336-0.08ML","price":205.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_29863fcd-a198-4c13-bdff-c01672afd4b0.jpg?v=1768362694","url":"https:\/\/danabiosci.com\/products\/nsj-f47336-0-08ml","provider":"Dana Bioscience","version":"1.0","type":"link"}