{"product_id":"nsj-f44236-0-08ml","title":"LIN28B Antibody, 0.08 ml","description":"\u003cp\u003eLin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":51552968376600,"sku":"F44236-0.08ML","price":205.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b18837b1-0fed-479d-964c-549afc63375a.jpg?v=1768363432","url":"https:\/\/danabiosci.com\/products\/nsj-f44236-0-08ml","provider":"Dana Bioscience","version":"1.0","type":"link"}