{"product_id":"nsj-f43338-0-4ml","title":"RIPK1 Antibody, 0.4 ml","description":"\u003cp\u003eEssential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51552997474584,"sku":"F43338-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_088fd516-f71b-4af9-abb4-f755081b6d4d.jpg?v=1768363841","url":"https:\/\/danabiosci.com\/products\/nsj-f43338-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}