{"product_id":"nsj-f42992-0-08ml","title":"NPC1 Antibody \/ Niemann Pick C1, 0.08 ml","description":"\u003cp\u003eThis gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal\/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal\/lysosomal compartments.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":51553004454168,"sku":"F42992-0.08ML","price":205.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7d114f34-dedd-4b91-85cf-8cc8bd4803dd.jpg?v=1768363980","url":"https:\/\/danabiosci.com\/products\/nsj-f42992-0-08ml","provider":"Dana Bioscience","version":"1.0","type":"link"}