{"product_id":"nsj-f42021-0-08ml","title":"ATF4 Antibody, 0.08 ml","description":"\u003cp\u003eATF4 is a transcriptional activator that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3\/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3\/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3\/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":51553014546712,"sku":"F42021-0.08ML","price":205.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b4aa98be-752c-4d1d-87c5-2c1ee091ff78.jpg?v=1768364213","url":"https:\/\/danabiosci.com\/products\/nsj-f42021-0-08ml","provider":"Dana Bioscience","version":"1.0","type":"link"}