{"product_id":"nsj-f40464-0-4ml","title":"KEAP1 Antibody, 0.4 ml","description":"\u003cp\u003eKEAP1 acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2\/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2\/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51553062027544,"sku":"F40464-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_f2f4c4bf-6156-4c98-8692-a48128521ed3.jpg?v=1768364682","url":"https:\/\/danabiosci.com\/products\/nsj-f40464-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}