{"product_id":"nsj-f40198-0-08ml","title":"SET07 Antibody \/ KMT5A, 0.08 ml","description":"\u003cp\u003eSET07 is a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53\/TP53 at 'Lys-382', leading to repress p53\/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":51553080574232,"sku":"F40198-0.08ML","price":205.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_87947775-6a70-400a-9eae-08979cdefa49.jpg?v=1768364986","url":"https:\/\/danabiosci.com\/products\/nsj-f40198-0-08ml","provider":"Dana Bioscience","version":"1.0","type":"link"}