{"product_id":"nsj-f40026-0-4ml","title":"GNAS Antibody, 0.4 ml","description":"\u003cp\u003eGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and\/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":51553106592024,"sku":"F40026-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_d7add99d-477b-4b35-ad68-c41bd5c25bdc.jpg?v=1768365477","url":"https:\/\/danabiosci.com\/products\/nsj-f40026-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}