{"product_id":"nsj-brat1-antibody-brca1-associated-atm-activator-1-primary-antibody","title":"BRAT1 Antibody \/ BRCA1 associated ATM activator 1","description":"\u003cp\u003eBRAT1 antibody detects BRCA1 associated ATM activator 1, a protein encoded by the BRAT1 gene. BRAT1 was originally identified as a BRCA1 binding partner and functions in DNA damage response, cell cycle regulation, and mitochondrial homeostasis. It contributes to ATM kinase activation, linking DNA double strand break recognition to checkpoint signaling and repair pathways.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;BRAT1 antibody is widely used in DNA damage research, cancer biology, and neurology. Mutations in BRAT1 cause autosomal recessive neurodevelopmental disorders characterized by seizures, microcephaly, and developmental delay. By detecting BRAT1, researchers can explore how DNA damage response proteins maintain genomic stability and neuronal health.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt; Western blot assays identify BRAT1 protein bands in nuclear and mitochondrial extracts. Immunohistochemistry highlights expression in proliferative and neural tissues, while immunofluorescence reveals nuclear and cytoplasmic localization. These methods provide robust tools for studying BRAT1 distribution and function.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;BRAT1 interacts with BRCA1, ATM, and DNA-PKcs, integrating multiple DNA repair pathways. Dysregulation of BRAT1 activity contributes to defective checkpoint signaling, apoptosis, and impaired mitochondrial function. In cancer research, BRAT1 has been linked to tumor suppression, but context-dependent roles suggest complex regulation. By applying BRAT1 antibody, scientists can study its roles in DNA repair, tumorigenesis, and neurological disease.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;BRAT1 antibody from NSJ Bioreagents provides strong specificity for studying BRAT1 function in DNA damage response and mitochondrial biology. Its reliable performance supports accurate detection across experimental systems.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable style=\"width:100%; border-collapse:collapse;\"\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFamily\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003ePrimary antibody\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormulation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormat\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eClone\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e29B86\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eHost Animal\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eClonality\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRecombinant Rabbit Monoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eIsotype\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWB, ICC, IF, IP, FACS\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Details\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWestern blot: 1:500-1:2000,Immunocytochemistry\/Immunofluorescence: 1:50-1:200,Immunoprecipitation: 1:50,Flow Cytometry: 1:50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Note\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eOptimal dilution of the BRAT1 antibody should be determined by the researcher.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eImmunogen\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eA synthesized peptide derived from human BRAT1 was used as the immunogen for the BRAT1 antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eBuffer\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePurity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAffinity-chromatography\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStorage\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eStore the BRAT1 antibody at -20oC.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eLimitation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eThis BRAT1 antibody is available for research use only.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eUniprot #\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eQ6PJG6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStatus\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAvailable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePDF Link\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e\u003ca href=\"http:\/\/www.nsjbio.com\/tds-pdf\/brat1-antibody-brca1-associated-atm-activator-1-fy12631-nsj-bioreagents\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttp:\/\/www.nsjbio.com\/tds-pdf\/brat1-antibody-brca1-associated-atm-activator-1-fy12631-nsj-bioreagents\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eTitle\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eBRAT1 Antibody \/ BRCA1 associated ATM activator 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eDescription\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eBRAT1 antibody detects BRCA1 associated ATM activator 1, a protein encoded by the BRAT1 gene. BRAT1 was originally identified as a BRCA1 binding partner and functions in DNA damage response, cell cycle regulation, and mitochondrial homeostasis. It contributes to ATM kinase activation, linking DNA double strand break recognition to checkpoint signaling and repair pathways.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;BRAT1 antibody is widely used in DNA damage research, cancer biology, and neurology. Mutations in BRAT1 cause autosomal recessive neurodevelopmental disorders characterized by seizures, microcephaly, and developmental delay. By detecting BRAT1, researchers can explore how DNA damage response proteins maintain genomic stability and neuronal health.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt; Western blot assays identify BRAT1 protein bands in nuclear and mitochondrial extracts. Immunohistochemistry highlights expression in proliferative and neural tissues, while immunofluorescence reveals nuclear and cytoplasmic localization. These methods provide robust tools for studying BRAT1 distribution and function.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;BRAT1 interacts with BRCA1, ATM, and DNA-PKcs, integrating multiple DNA repair pathways. Dysregulation of BRAT1 activity contributes to defective checkpoint signaling, apoptosis, and impaired mitochondrial function. In cancer research, BRAT1 has been linked to tumor suppression, but context-dependent roles suggest complex regulation. By applying BRAT1 antibody, scientists can study its roles in DNA repair, tumorigenesis, and neurological disease.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;BRAT1 antibody from NSJ Bioreagents provides strong specificity for studying BRAT1 function in DNA damage response and mitochondrial biology. Its reliable performance supports accurate detection across experimental systems.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51543788749080,"sku":"FY12631","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_76870b59-cd44-47e7-93f1-651dd4fee8e2.jpg?v=1768137254","url":"https:\/\/danabiosci.com\/products\/nsj-brat1-antibody-brca1-associated-atm-activator-1-primary-antibody","provider":"Dana Bioscience","version":"1.0","type":"link"}