{"product_id":"nsj-aqcbl-reductase-antibody-aquacobalamin-reductase-mtrr-primary-antibody","title":"AqCbl reductase Antibody \/ Aquacobalamin reductase \/ MTRR","description":"\u003cp\u003eAqCbl reductase, also known as aquacobalamin reductase, is a key enzyme involved in the intracellular metabolism of cobalamin (vitamin B12). It catalyzes the reduction of aquacobalamin to cob(II)alamin, a critical step in the conversion of dietary cobalamin into its biologically active cofactor forms--methylcobalamin and adenosylcobalamin. These active forms are essential for proper DNA synthesis, red blood cell formation, and neurological function. AqCbl reductase ensures that cobalamin is maintained in a reduced state, facilitating its uptake and utilization in various metabolic pathways.\u0026lt;p\u0026gt;Dysregulation of AqCbl reductase activity can disrupt cobalamin homeostasis and is associated with metabolic disorders, including methylmalonic acidemia and homocystinuria. Given its pivotal role in cobalamin processing, AqCbl reductase has emerged as a critical marker in studies of vitamin B12 metabolism and related diseases. Researchers have also explored its function in oxidative stress responses and mitochondrial health.\u0026lt;p\u0026gt;The AqCbl reductase antibody enables specific detection of this enzyme in biological samples, supporting studies of cobalamin-dependent metabolic pathways. It is widely used in western blot, immunohistochemistry, and ELISA applications to investigate tissue-specific expression patterns and disease-related changes. With proven performance and high specificity, the AqCbl reductase antibody is an indispensable tool for scientists exploring vitamin B12 metabolism. Incorporating the AqCbl reductase antibody into your research workflow provides valuable insights into the regulation and function of this essential metabolic enzyme.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable style=\"width:100%; border-collapse:collapse;\"\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFamily\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003ePrimary antibody\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormulation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e0.5mg\/ml if reconstituted with 0.2ml sterile DI water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormat\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAntigen affinity purified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eHost Animal\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eClonality\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003ePolyclonal (rabbit origin)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eIsotype\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eHuman, Mouse, Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWB, FACS, IHC-P, IF, Direct ELISA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Details\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWestern blot: 0.5-1 ug\/ml,Flow cytometry: 1-3ug\/ml,Direct ELISA: 0.1-0.5ug\/ml,Immunohistochemistry (FFPE): 2-5ug\/ml,Immunofluorescence: 5ug\/ml,Immunoprecipitation: 2ug per 500ug of lysate\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Note\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eOptimal dilution of the AqCbl reductase antibody should be determined by the researcher.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eLocalization\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eCytoplasm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eImmunogen\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRecombinant human protein (amino acids L7-S698) was used as the immunogen for the AqCbl reductase antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eBuffer\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eLyophilized from 1X PBS with 2% Trehalose\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePurity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAntigen affinity purified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStorage\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAfter reconstitution, the AqCbl reductase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eLimitation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eThis AqCbl reductase antibody is available for research use only.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eUniprot #\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eQ9UBK8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStatus\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAvailable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePDF Link\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e\u003ca href=\"http:\/\/www.nsjbio.com\/tds-pdf\/aqcbl-reductase-antibody-aquacobalamin-reductase-mtrr-rq8878\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttp:\/\/www.nsjbio.com\/tds-pdf\/aqcbl-reductase-antibody-aquacobalamin-reductase-mtrr-rq8878\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eTitle\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAqCbl reductase Antibody \/ Aquacobalamin reductase \/ MTRR\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eDescription\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAqCbl reductase, also known as aquacobalamin reductase, is a key enzyme involved in the intracellular metabolism of cobalamin (vitamin B12). It catalyzes the reduction of aquacobalamin to cob(II)alamin, a critical step in the conversion of dietary cobalamin into its biologically active cofactor forms--methylcobalamin and adenosylcobalamin. These active forms are essential for proper DNA synthesis, red blood cell formation, and neurological function. AqCbl reductase ensures that cobalamin is maintained in a reduced state, facilitating its uptake and utilization in various metabolic pathways.\u0026lt;p\u0026gt;Dysregulation of AqCbl reductase activity can disrupt cobalamin homeostasis and is associated with metabolic disorders, including methylmalonic acidemia and homocystinuria. Given its pivotal role in cobalamin processing, AqCbl reductase has emerged as a critical marker in studies of vitamin B12 metabolism and related diseases. Researchers have also explored its function in oxidative stress responses and mitochondrial health.\u0026lt;p\u0026gt;The AqCbl reductase antibody enables specific detection of this enzyme in biological samples, supporting studies of cobalamin-dependent metabolic pathways. It is widely used in western blot, immunohistochemistry, and ELISA applications to investigate tissue-specific expression patterns and disease-related changes. With proven performance and high specificity, the AqCbl reductase antibody is an indispensable tool for scientists exploring vitamin B12 metabolism. Incorporating the AqCbl reductase antibody into your research workflow provides valuable insights into the regulation and function of this essential metabolic enzyme.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51543780884760,"sku":"RQ8878","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_709acc1f-a95f-42bc-ba5a-ddb7c67f817b.jpg?v=1768136829","url":"https:\/\/danabiosci.com\/products\/nsj-aqcbl-reductase-antibody-aquacobalamin-reductase-mtrr-primary-antibody","provider":"Dana Bioscience","version":"1.0","type":"link"}