{"product_id":"nsj-ap2m1-antibody-ap-2-complex-subunit-mu-primary-antibody","title":"AP2M1 Antibody \/ AP-2 complex subunit mu","description":"\u003cp\u003eAP2M1 (Adaptor-related protein complex 2 subunit mu 1, AP-2 complex subunit mu) is a critical component of the adaptor protein 2 (AP-2) complex, which is essential for clathrin-mediated endocytosis. This process is responsible for the internalization of receptors, nutrients, and other molecules from the plasma membrane into endocytic vesicles. AP2M1 acts as the medium (mu) subunit of the complex and is directly involved in cargo recognition by binding to specific endocytic motifs on membrane proteins. A AP2M1 antibody is frequently used to study endocytosis, receptor trafficking, and membrane dynamics.    \u0026lt;br\u0026gt;\u0026lt;br\u0026gt;  The AP-2 complex consists of two large subunits (alpha and beta), one medium subunit (mu, encoded by AP2M1), and one small subunit (sigma). Together, they coordinate clathrin recruitment and vesicle formation. AP2M1 is particularly important because of its ability to recognize tyrosine-based sorting signals on transmembrane receptors, ensuring selective cargo uptake. Employing a AP2M1 antibody allows researchers to examine receptor internalization, vesicle trafficking, and signal transduction.    \u0026lt;br\u0026gt;\u0026lt;br\u0026gt;  Alterations in AP2M1 function have been implicated in neurological disorders and developmental abnormalities, as proper endocytic trafficking is vital for synaptic vesicle recycling and neuronal signaling. Dysregulation of AP2M1-mediated pathways may also contribute to cancer progression, viral entry, and other disease processes. Using a AP2M1 antibody provides valuable insights into these mechanisms and helps researchers explore therapeutic strategies targeting endocytic pathways.    \u0026lt;br\u0026gt;\u0026lt;br\u0026gt;  NSJ Bioreagents provides a high-quality AP2M1 antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing an AP2M1 antibody from NSJ Bioreagents ensures reproducible results and reliable detection in studies of endocytosis, receptor trafficking, and cellular signaling.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable style=\"width:100%; border-collapse:collapse;\"\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFamily\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003ePrimary antibody\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormulation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e0.5mg\/ml if reconstituted with 0.2ml sterile DI water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormat\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAntigen affinity purified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eHost Animal\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eClonality\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003ePolyclonal (rabbit origin)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eIsotype\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eHuman, Mouse, Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWB, IHC-P, IF, FACS, ELISA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Details\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWestern blot: 1-2ug\/ml,Immunohistochemistry (FFPE): 2-5ug\/ml,ELISA: 0.1-0.5ug\/ml,Immunofluorescence: 5ug\/ml,Flow cytometry: 1-3ug\/million cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Note\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eOptimal dilution of the AP2M1 antibody should be determined by the researcher.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eLocalization\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eCytoplasm, cell membrane\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eImmunogen\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAmino acids N9-C435 from the human protein were used as the immunogen for the AP2M1 antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eBuffer\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eLyophilized from 1X PBS with 2% Trehalose\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePurity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAntigen affinity purified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStorage\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAfter reconstitution, the AP2M1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eLimitation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eThis AP2M1 antibody is available for research use only.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eUniprot #\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eQ96CW1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStatus\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAvailable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePDF Link\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e\u003ca href=\"http:\/\/www.nsjbio.com\/tds-pdf\/ap2m1-antibody-ap-2-complex-subunit-mu-rq8929\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttp:\/\/www.nsjbio.com\/tds-pdf\/ap2m1-antibody-ap-2-complex-subunit-mu-rq8929\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eTitle\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAP2M1 Antibody \/ AP-2 complex subunit mu\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eDescription\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAP2M1 (Adaptor-related protein complex 2 subunit mu 1, AP-2 complex subunit mu) is a critical component of the adaptor protein 2 (AP-2) complex, which is essential for clathrin-mediated endocytosis. This process is responsible for the internalization of receptors, nutrients, and other molecules from the plasma membrane into endocytic vesicles. AP2M1 acts as the medium (mu) subunit of the complex and is directly involved in cargo recognition by binding to specific endocytic motifs on membrane proteins. A AP2M1 antibody is frequently used to study endocytosis, receptor trafficking, and membrane dynamics.    \u0026lt;br\u0026gt;\u0026lt;br\u0026gt;  The AP-2 complex consists of two large subunits (alpha and beta), one medium subunit (mu, encoded by AP2M1), and one small subunit (sigma). Together, they coordinate clathrin recruitment and vesicle formation. AP2M1 is particularly important because of its ability to recognize tyrosine-based sorting signals on transmembrane receptors, ensuring selective cargo uptake. Employing a AP2M1 antibody allows researchers to examine receptor internalization, vesicle trafficking, and signal transduction.    \u0026lt;br\u0026gt;\u0026lt;br\u0026gt;  Alterations in AP2M1 function have been implicated in neurological disorders and developmental abnormalities, as proper endocytic trafficking is vital for synaptic vesicle recycling and neuronal signaling. Dysregulation of AP2M1-mediated pathways may also contribute to cancer progression, viral entry, and other disease processes. Using a AP2M1 antibody provides valuable insights into these mechanisms and helps researchers explore therapeutic strategies targeting endocytic pathways.    \u0026lt;br\u0026gt;\u0026lt;br\u0026gt;  NSJ Bioreagents provides a high-quality AP2M1 antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing an AP2M1 antibody from NSJ Bioreagents ensures reproducible results and reliable detection in studies of endocytosis, receptor trafficking, and cellular signaling.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51543752474904,"sku":"RQ8929","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_88af5c44-c8d9-4a24-bbbf-4e2c8053b2a5.jpg?v=1768135705","url":"https:\/\/danabiosci.com\/products\/nsj-ap2m1-antibody-ap-2-complex-subunit-mu-primary-antibody","provider":"Dana Bioscience","version":"1.0","type":"link"}