{"product_id":"nsj-alpha-tubulin-acetyl-k40-antibody-tuba1b-tuba4a-primary-antibody","title":"Alpha Tubulin (acetyl K40) Antibody \/ TUBA1B\/TUBA4A","description":"\u003cp\u003eAlpha Tubulin (acetyl K40) antibody detects alpha tubulin specifically when acetylated at lysine 40. Alpha tubulin, encoded by multiple genes including TUBA1A, TUBA3C, and TUBA4A, is one of the two principal subunits of microtubules, the dynamic cytoskeletal polymers critical for cell shape, intracellular transport, and mitotic spindle formation. Common alternate identifiers include TUBA1 and TUBA4, which are widely referenced in literature. Acetylation of lysine 40 is a well known post translational modification associated with stable, long lived microtubules that support transport and signaling.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Alpha Tubulin (acetyl K40) antibody is widely applied in cell biology, neurobiology, and cancer research. Microtubule acetylation is enriched in neuronal axons, cilia, and stable cytoskeletal structures. By detecting acetylation at lysine 40, researchers can evaluate how microtubules achieve stability and how post translational modifications regulate cytoskeletal dynamics.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt; Immunofluorescence with Alpha Tubulin (acetyl K40) antibody highlights stable microtubule tracks in neurons and ciliated cells. Immunohistochemistry maps tissue regions enriched in acetylated tubulin, while western blotting detects the modified isoform as distinct from total tubulin. These assays provide powerful tools for studying cytoskeletal regulation.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Acetylation at lysine 40 is mediated by alpha tubulin acetyltransferase (ATAT1) and reversed by histone deacetylase 6. Dysregulation of this balance contributes to neurodegenerative disease, cancer, and ciliopathies. By applying this phospho specific antibody, scientists can examine mechanisms of axonal transport, sensory signaling, and tumor progression.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Alpha Tubulin (acetyl K40) antibody from NSJ Bioreagents provides strong specificity for detecting this critical post translational modification. Its performance supports both basic and translational studies of microtubule biology.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable style=\"width:100%; border-collapse:collapse;\"\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFamily\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003ePrimary antibody\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormulation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormat\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eClone\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e31T79\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eHost Animal\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eClonality\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRecombinant Rabbit Monoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eIsotype\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eHuman, Mouse, Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWB, IHC, ICC, IF, IP, FACS\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Details\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWestern blot: 1:500-1:2000,Immunohistochemistry: 1:50-1:200,Immunocytochemistry\/Immunofluorescence: 1:50-1:200,Immunoprecipitation: 1:50,Flow Cytometry: 1:50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Note\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eOptimal dilution of the Alpha Tubulin (acetyl K40) antibody should be determined by the researcher.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eImmunogen\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eA synthesized peptide derived from human alpha Tubulin (acetyl K40) was used as the immunogen for the Alpha Tubulin (acetyl K40) antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eBuffer\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePurity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAffinity-chromatography\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStorage\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eStore the Alpha Tubulin (acetyl K40) antibody at -20oC.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eLimitation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eThis Alpha Tubulin (acetyl K40) antibody is available for research use only.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eUniprot #\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eP68363, P68366\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStatus\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAvailable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePDF Link\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e\u003ca href=\"http:\/\/www.nsjbio.com\/tds-pdf\/alpha-tubulin-acetyl-k40-antibody-tuba1b-tuba4a-fy12718-nsj-bioreagents\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttp:\/\/www.nsjbio.com\/tds-pdf\/alpha-tubulin-acetyl-k40-antibody-tuba1b-tuba4a-fy12718-nsj-bioreagents\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eTitle\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAlpha Tubulin (acetyl K40) Antibody \/ TUBA1B\/TUBA4A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eDescription\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAlpha Tubulin (acetyl K40) antibody detects alpha tubulin specifically when acetylated at lysine 40. Alpha tubulin, encoded by multiple genes including TUBA1A, TUBA3C, and TUBA4A, is one of the two principal subunits of microtubules, the dynamic cytoskeletal polymers critical for cell shape, intracellular transport, and mitotic spindle formation. Common alternate identifiers include TUBA1 and TUBA4, which are widely referenced in literature. Acetylation of lysine 40 is a well known post translational modification associated with stable, long lived microtubules that support transport and signaling.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Alpha Tubulin (acetyl K40) antibody is widely applied in cell biology, neurobiology, and cancer research. Microtubule acetylation is enriched in neuronal axons, cilia, and stable cytoskeletal structures. By detecting acetylation at lysine 40, researchers can evaluate how microtubules achieve stability and how post translational modifications regulate cytoskeletal dynamics.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt; Immunofluorescence with Alpha Tubulin (acetyl K40) antibody highlights stable microtubule tracks in neurons and ciliated cells. Immunohistochemistry maps tissue regions enriched in acetylated tubulin, while western blotting detects the modified isoform as distinct from total tubulin. These assays provide powerful tools for studying cytoskeletal regulation.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Acetylation at lysine 40 is mediated by alpha tubulin acetyltransferase (ATAT1) and reversed by histone deacetylase 6. Dysregulation of this balance contributes to neurodegenerative disease, cancer, and ciliopathies. By applying this phospho specific antibody, scientists can examine mechanisms of axonal transport, sensory signaling, and tumor progression.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Alpha Tubulin (acetyl K40) antibody from NSJ Bioreagents provides strong specificity for detecting this critical post translational modification. Its performance supports both basic and translational studies of microtubule biology.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51543767351576,"sku":"FY12718","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_5ffa8148-57aa-4927-8ccf-45b1e9d52b81.jpg?v=1768136372","url":"https:\/\/danabiosci.com\/products\/nsj-alpha-tubulin-acetyl-k40-antibody-tuba1b-tuba4a-primary-antibody","provider":"Dana Bioscience","version":"1.0","type":"link"}