{"product_id":"nsj-acap2-antibody-arfgap-with-coiled-coil-ankyrin-repeat-and-ph-domains-2-primary-antibody","title":"ACAP2 Antibody \/ ArfGAP with coiled-coil ankyrin repeat and PH domains 2","description":"\u003cp\u003eACAP2 antibody detects ArfGAP with coiled-coil, ankyrin repeat, and PH domains 2, a GTPase-activating protein that regulates ADP-ribosylation factor 6 (ARF6). ACAP2 controls membrane trafficking and actin cytoskeleton remodeling by accelerating the hydrolysis of ARF6-bound GTP. Through these functions, ACAP2 coordinates processes such as endocytosis, recycling, and cell migration.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Research using ACAP2 antibody demonstrates its role in neuronal and immune cell biology. In neurons, ACAP2 regulates dendritic spine development and axon guidance by modulating actin remodeling. In immune cells, ACAP2 contributes to receptor trafficking and migration, influencing both innate and adaptive responses. Dysregulation of ACAP2 has been associated with impaired immune function and altered neuronal connectivity.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;ACAP2 is also studied in cancer and viral infections. Tumor cells exploit ARF6 signaling pathways to promote invasion and metastasis, and ACAP2 acts as a regulator of this activity. Reduced ACAP2 expression can enhance ARF6-mediated oncogenic signaling. Viral pathogens, including some RNA viruses, utilize ARF6 and its regulators to facilitate replication and budding, suggesting ACAP2 may indirectly impact host-pathogen interactions.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Antibodies against ACAP2 are validated for western blot, immunofluorescence, and immunohistochemistry. These reagents allow researchers to investigate protein localization, expression levels, and interactions with ARF6 and related molecules. Clone-based antibodies provide specificity to ensure consistent results across experimental systems.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;NSJ Bioreagents supplies this ACAP2 antibody for studies in membrane trafficking, cytoskeletal regulation, and signaling pathways.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable style=\"width:100%; border-collapse:collapse;\"\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFamily\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003ePrimary antibody\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormulation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eFormat\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eClone\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e30A18\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eHost Animal\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eClonality\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRecombinant Rabbit Monoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eIsotype\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eHuman, Mouse, Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWB\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Details\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eWestern blot: 1:500-1:2000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eApplication Note\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eOptimal dilution of the ACAP2 antibody should be determined by the researcher.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eImmunogen\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eA synthesized peptide derived from human ACAP2 was used as the immunogen for the ACAP2 antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eBuffer\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eRabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePurity\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAffinity-chromatography\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStorage\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eStore the ACAP2 antibody at -20oC.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eLimitation\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eThis ACAP2 antibody is available for research use only.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eUniprot #\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eQ15057\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eStatus\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eAvailable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003ePDF Link\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003e\u003ca href=\"http:\/\/www.nsjbio.com\/tds-pdf\/acap2-antibody-arfgap-with-coiled-coil-ankyrin-repeat-and-ph-domains-2-fy12131-nsj-bioreagents\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttp:\/\/www.nsjbio.com\/tds-pdf\/acap2-antibody-arfgap-with-coiled-coil-ankyrin-repeat-and-ph-domains-2-fy12131-nsj-bioreagents\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eTitle\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eACAP2 Antibody \/ ArfGAP with coiled-coil ankyrin repeat and PH domains 2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left; vertical-align:top; padding:6px; border-bottom:1px solid #eee;\"\u003eDescription\u003c\/th\u003e\n\u003ctd style=\"padding:6px; border-bottom:1px solid #eee;\"\u003eACAP2 antibody detects ArfGAP with coiled-coil, ankyrin repeat, and PH domains 2, a GTPase-activating protein that regulates ADP-ribosylation factor 6 (ARF6). ACAP2 controls membrane trafficking and actin cytoskeleton remodeling by accelerating the hydrolysis of ARF6-bound GTP. Through these functions, ACAP2 coordinates processes such as endocytosis, recycling, and cell migration.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Research using ACAP2 antibody demonstrates its role in neuronal and immune cell biology. In neurons, ACAP2 regulates dendritic spine development and axon guidance by modulating actin remodeling. In immune cells, ACAP2 contributes to receptor trafficking and migration, influencing both innate and adaptive responses. Dysregulation of ACAP2 has been associated with impaired immune function and altered neuronal connectivity.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;ACAP2 is also studied in cancer and viral infections. Tumor cells exploit ARF6 signaling pathways to promote invasion and metastasis, and ACAP2 acts as a regulator of this activity. Reduced ACAP2 expression can enhance ARF6-mediated oncogenic signaling. Viral pathogens, including some RNA viruses, utilize ARF6 and its regulators to facilitate replication and budding, suggesting ACAP2 may indirectly impact host-pathogen interactions.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Antibodies against ACAP2 are validated for western blot, immunofluorescence, and immunohistochemistry. These reagents allow researchers to investigate protein localization, expression levels, and interactions with ARF6 and related molecules. Clone-based antibodies provide specificity to ensure consistent results across experimental systems.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;NSJ Bioreagents supplies this ACAP2 antibody for studies in membrane trafficking, cytoskeletal regulation, and signaling pathways.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51543740121368,"sku":"FY12131","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_12e23eeb-b945-463b-818e-6847af02dab4.jpg?v=1768135100","url":"https:\/\/danabiosci.com\/products\/nsj-acap2-antibody-arfgap-with-coiled-coil-ankyrin-repeat-and-ph-domains-2-primary-antibody","provider":"Dana Bioscience","version":"1.0","type":"link"}