{"product_id":"new-product-702056","title":"JAK1 Rabbit mAb","description":"\u003cp\u003eThis gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha\/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)\/JAK1\/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":48578060288280,"sku":"A11963","price":368.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/new-product-702056","provider":"Dana Bioscience","version":"1.0","type":"link"}